Technology & AISignal

Chinese Researchers Unveil AI-Powered Imaging System to Visualize Acupuncture Effects

A research team from China has developed RUSH3D-HR, an AI-enabled mesoscopic imaging system that tracks cellular changes triggered by acupuncture in live animals.

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The Brief

China News Service reported that a Chinese research team unveiled a new AI-enabled living mesoscopic three-dimensional microscopic imaging system named RUSH3D-HR at the 2026 World Traditional Medicine Congress in Beijing. The study captured real-time cellular dynamics in distal immune organs regulated by acupuncture in live animals for the first time, providing visual cellular evidence for traditional acupuncture therapy. Jointly developed by teams led by Academician Dai Qionghai of Tsinghua University and Professor Wang Wei of Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology, the research was published in Nature Biotechnology. Co-first author Lu Zhi, an assistant professor at Tsinghua University, described the project as an attempt to interpret traditional medicine using modern scientific language. In an acute inflammation mouse model, the team found that applying a 0.5 milliampere electroacupuncture intervention to the Zusanli acupoint reduced neutrophil clustering events by more than 5 times. The experimental results confirmed the anti-inflammatory regulatory effects of electroacupuncture at the level of cellular dynamics. To capture these dynamic processes, the researchers developed the Kunlun objective lens featuring a large field of view and high numerical aperture, maintaining subcellular resolution across a millimeter-scale field. Integrating computational imaging and artificial intelligence algorithms enabled motion artifact correction, noise reduction, and three-dimensional reconstruction.

China context

In the mouse acute inflammation model, spleen neutrophil numbers increased by about 30%, forming clusters of hundreds of cells roughly 10 times as frequently as in normal mice.

Key Takeaways

  • 1Researchers developed RUSH3D-HR to capture real-time cellular immune responses during acupuncture in live animals.
  • 2Applying a 0.5 milliampere electroacupuncture intervention to mouse Zusanli acupoints reduced neutrophil clusters over 5 times.
  • 3The Kunlun objective lens combined with artificial intelligence algorithms achieves millimeter-scale imaging at subcellular resolution.

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